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Renal disease is very prevalent in the dog and cat populations with one form of renal disease, Chronic Kidney Failure (CKD) having an incidence of 1.6% (~ 1.4 million cats in the US alone) of the total cat population and 0.9% (~ 675,000 dogs in the US alone) of the total dog (Veterinary Medical Data Base, University of Purdue). Age and breed are both risk factors for the disease in both species. According to the International Renal Interest Society (IRIS) some form of cat kidney disease is present in almost every cat over the age of 9. Tubulointerstitial diseases are a common cause of CKD in cats. Other clinical factors: sequelae of acute renal failure, urinary tract infections, urinary stones, obstruction of lower urinary tract, diabetes, hypercalcemia, heart failure. Drugs such as aminoglycosides, sulfonamides, polymyxin B, amphotericin and chemotherapeutic drugs are also associated with the triggering CKD. Progression factors for CKD include high blood pressure, high level of proteinuria, poor glycemic control and diabetes mellitus.

Bimini’s Best™ Cat Kidney Health Supplement is designed to support proper cat kidney health and function. The edible backbone gives the pet a more natural and familiar delivery form that does not involve pills, powders or potions making it a better experience for both the pet owner and cat.

The active constituents include:

  • Root of Rehmannia glutinosa. Constituents include: Iridoids, such as ajugol and rehmanniosides and phenylethanoid glycosides such as verbascoside and echinacoside. This herb has anti-inflammatory and diuretic actions.
  • Root of Astragalus membranaceus; similar species include Astragalus floridus, tonglensis and chrysopterus. Constituents include: Triterpene saponins (astragalosides I-X and isoastragalosides I-IV) as well as astragalan and astraglucan. This herb has many hypotensive as well as renal protective functions.

Supporting Publications:

Rehmannia:

Kang, D. G., Sohn, E.J., Moon, M.K., Lee Y. M., Lee, H.S. Rhemannia glutinose ameliorates renal function in the ischemia/reperfusion-induced acute renal failure rats. Biol Pharm Bull 2005, 28:1662-1667. 

http://www.ncbi.nlm.nih.gov/pubmed/16141536

Yokozawa, T., Kim, H.Y., Yamabe, N. Amelioration of diabetic nephropathy by dried rhemannia Radix (Di Huang) extract. Am J. Chin Med 2004, 32:829-839.

http://www.ncbi.nlm.nih.gov/pubmed/15673189

 

Astragalus:

Leehey DJ, Casini T, Massey D. Remission of membranous nephropathy after therapy with Astragalus membranaceus. Am J Kidney Dis. 2010 Apr;55(4):772. 
http://www.ncbi.nlm.nih.gov/pubmed/?term=20338467

 

Yu SY, Ouyang HT, Yang JY, Huang XL, Yang T, Duan JP, Cheng JP, Chen YX, Yang YJ, Qiong P. Subchronic toxicity studies of Radix Astragali extract in rats anddogs. J Ethnopharmacol. 2007 Mar 21;110(2):352-5. Epub 2006 Sep 27.
http://www.ncbi.nlm.nih.gov/pubmed/?term=17052876

 

Zhang WD, Zhang C, Liu RH, Li HL, Zhang JT, Mao C, Moran S, Chen CL. Preclinical pharmacokinetics and tissue distribution of a natural cardioprotective agent astragaloside IV in rats and dogs. Life Sci. 2006 Jul 17;79(8):808-15. Epub 2006 Mar 29.
http://www.ncbi.nlm.nih.gov/pubmed/?term=16564551

 

Yin, X., Zhang, Y., Wu, H., et al. Protective Effects of Astragalus Saponin I on early stages of diabetic nephropathy in rats. J. Pharmacol. Sci 2004, 95:256-266.

http://www.ncbi.nlm.nih.gov/pubmed/15215651

  

Astragalus/Rehmannia Combination Study:


Su ZZ, He YY, Chen G. [Clinical and experimental study on effects of man-shen-ling oral liquid in the treatment of 100 cases of chronic nephritis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 May;13(5):269-72, 259-60. Chinese.
http://www.ncbi.nlm.nih.gov/pubmed/?term=8219675

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